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Malarial infection during pregnancy

H M Silver1

  • 1Department of Maternal-Fetal Medicine, Women & Infants Hospital of Rhode Island, Providence, USA.

Infectious Disease Clinics of North America
|March 1, 1997
PubMed
Summary
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This review covers malaria in pregnancy, detailing susceptibility, clinical effects, and perinatal outcomes. It also discusses safe antimalarial treatments and prevention strategies for endemic regions.

Area of Science:

  • Medical Parasitology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Malaria poses significant risks during pregnancy, increasing susceptibility and severity.
  • Pregnancy alters the clinical presentation and immunological response to malaria.
  • Adverse perinatal outcomes are strongly associated with malaria infection in pregnant individuals.

Purpose of the Study:

  • To provide a comprehensive review of malaria in pregnancy.
  • To elucidate the pathogenesis of increased susceptibility and altered clinical manifestations.
  • To summarize current knowledge on antimalarial safety, chemoprophylaxis, and treatment.

Main Methods:

  • Literature review of parasitology, epidemiology, and clinical management of malaria in pregnancy.

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  • Synthesis of data on pathogenesis, clinical effects, and perinatal outcomes.
  • Evaluation of safety profiles for antimalarial drugs and chemoprophylaxis.

    • Main Results:

    • Pregnancy enhances susceptibility to malaria, particularly Plasmodium falciparum.
    • Malaria infection during pregnancy can lead to severe maternal anemia, placental pathology, and poor birth outcomes.
    • Several antimalarial agents are considered safe for use during pregnancy, with specific recommendations for chemoprophylaxis and treatment.

    Conclusions:

    • Malaria in pregnancy requires careful management due to risks to both mother and fetus.
    • Chemoprophylaxis and prompt, safe treatment are crucial for preventing adverse outcomes.
    • Further research is needed to optimize prevention and treatment strategies in endemic areas.