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Pimozide (Orap) in patients with pseudo-neurotic behaviour
Acta Psychiatrica Belgica
|March 1, 1977
Summary
Pimozide, an antipsychotic, showed significant improvement in pseudo-neurotic patients over ten weeks. Patients experienced better psychiatric symptoms and socio-professional adaptation, with some needing additional antiparkinsonian medication.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Investigating the efficacy of pimozide in treating pseudo-neurotic conditions.
- Assessing pimozide's impact on psychiatric symptoms and daily functioning.
Observation:
- 44 patients with pseudo-neuroticism received pimozide (2-12 mg daily) for ten weeks.
- Concurrent use of previously ineffective tranquilizers was permitted.
- Dexetimide, an antiparkinsonian agent, was available for use if necessary.
Findings:
- A significant majority of patients showed considerable improvement across Wittenborn psychiatric scale items.
- Socio-professional adaptation demonstrated a parallel positive trend.
- Four patients required dexetimide, particularly those on higher pimozide doses.
Implications:
- Pimozide demonstrates therapeutic potential for pseudo-neurotic patients.
- Further research into optimal dosing and adjunctive therapies is warranted.
- Understanding the need for antiparkinsonian agents at higher doses is crucial.