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Related Experiment Videos

Bleeding esophageal ulcers caused by NSAIDs

C Sugawa1, Y Takekuma, C E Lucas

  • 1Department of Surgery, Wayne State University School of Medicine, 6-C, University Health Center, 4201 St. Antoine, Detroit, MI 48201, USA.

Surgical Endoscopy
|February 1, 1997
PubMed
Summary

Nonsteroidal anti-inflammatory drug (NSAID) use can cause esophageal ulcers, leading to symptoms like anemia and pain. Early diagnosis via endoscopy and prompt treatment are crucial for healing.

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Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation.
  • Esophageal injury from NSAIDs is a recognized but often underdiagnosed complication.

Observation:

  • Four patients presented with NSAID-induced esophageal ulcers, confirmed by endoscopy.
  • Common symptoms included anemia, retrosternal pain, and dysphagia.
  • Ulcers were often large, shallow, and located in the mid-esophagus.

Findings:

  • Three patients experienced bleeding esophageal ulcers requiring transfusions.
  • One patient had massive bleeding successfully managed with endoscopic hemostasis.
  • Endoscopic follow-up showed ulcer healing within 3-4 weeks after treatment initiation.

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Implications:

  • NSAID-induced esophageal ulcers have distinct endoscopic features.
  • Early diagnosis through precise history and endoscopy is critical.
  • Treatment involves discontinuing NSAIDs, antacids, H2 blockers, and patient counseling on medication intake.