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Related Experiment Videos

Cutaneous aspergillosis

W F Smith1, M R Wallace

  • 1Department of Dermatology, Naval Medical Center, San Diego, California 92134-5000, USA.

Cutis
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

A skin lesion in an advanced human immunodeficiency virus (HIV) patient under a venous catheter dressing was caused by Aspergillus fumigatus. This fungal infection highlights the importance of considering Aspergillus in HIV-associated skin conditions.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Advanced acquired immunodeficiency syndrome (AIDS) compromises the immune system, increasing susceptibility to opportunistic infections.
  • Cutaneous lesions can manifest in immunocompromised individuals, requiring thorough differential diagnosis.
  • Indwelling venous catheters are common in patients with advanced HIV, posing risks for infection.

Observation:

  • A patient with advanced AIDS developed a distinct cutaneous lesion beneath a transparent dressing covering a venous catheter.
  • Histopathological analysis of the lesion revealed suppurative granulomatous inflammation.
  • Microscopic examination identified numerous branching hyphae within the follicular infundibulum of the dermis.

Findings:

  • Fungal culture of the biopsy specimen successfully isolated Aspergillus fumigatus.

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  • The presence of Aspergillus fumigatus hyphae within hair follicles suggests a specific route of infection.
  • The occlusive nature of the dressing likely facilitated fungal proliferation.

    • Implications:

    • Aspergillus fumigatus should be included in the differential diagnosis for cutaneous lesions in human immunodeficiency virus (HIV)-infected patients.
    • Particular vigilance is required when such lesions appear under occlusive dressings, such as those used for venous catheters.
    • Early recognition and appropriate antifungal treatment are crucial for managing invasive fungal infections in immunocompromised individuals.