Related Experiment Video
Updated: Aug 11, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
[State of cardiovascular and blood coagulation systems during prolonged exposure to extreme stimuli]
Abstract:
The studies covered complex effects of local shock vibration at extreme levels and ambient heat load with intensive impulse noise and general vibration in association with heavy physical work. The experiments on animals assessed influence of low temperatures on cardiovascular and hemocoagulation systems. Analysis of those clinical and experimental data proved that extreme and subextreme levels of long-acting factors induce disorders of hemostasis-depression of anticoagulation, that is similar to 1 phase of DIC syndrome. These results are important for diagnosis of premorbid and pathologic conditions.
Related Concept Videos
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Vascular Spasm
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Acute Inflammation III: Local and Systemic Effects

