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[Human erythrocyte glycerides]

J Etienne, L Noe, M Krulik

    Annales De Biologie Clinique
    |January 1, 1977
    PubMed
    Summary
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    Measuring red cell glycerides is challenging due to their low concentration compared to other lipids. Erythrocytes contain both diglycerides and triglycerides, unlike serum which primarily has triglycerides.

    Area of Science:

    • Biochemistry
    • Hematology
    • Lipid Metabolism

    Context:

    • Erythrocytes (red blood cells) contain significantly lower concentrations of glycerides compared to other blood lipids like cholesterol and phospholipids.
    • Existing serum glyceride assays require modification to account for the lipid composition differences in red blood cells.

    Purpose:

    • To highlight the challenges in accurately quantifying glycerides within erythrocytes.
    • To differentiate the glyceride composition in erythrocytes from that found in serum.

    Summary:

    • Red blood cells contain very low levels of glycerides (approx. 5mg/L), which are 200-500 times less abundant than cholesterol and phospholipids.
    • Erythrocyte glyceride analysis necessitates the removal of interfering lipids.
    • Unlike serum, which is rich in triglycerides, erythrocytes contain both diglycerides and triglycerides.

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    Impact:

    • Improved understanding of red blood cell lipid profiles.
    • Potential for development of more accurate diagnostic methods for erythrocyte glycerides.
    • Foundation for further research into the specific roles of erythrocyte glycerides in cellular function and disease.