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Hepatitis-associated lipid storage myopathy

B M Patten, J M Shabot, J Alperin

Annals of Internal Medicine

|October 1, 1977

Summary

This summary is machine-generated.

Hepatitis B virus infection can cause lipid storage myopathy, a condition characterized by muscle pain and lipid accumulation. Treatment with prednisone effectively resolved symptoms, suggesting a non-carnitine-deficient cause.

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Area of Science:

Hepatology
Neurology
Immunology

Background:

Hepatitis B virus (HBV) infection is a significant global health concern.
Lipid storage myopathies are a group of rare genetic disorders affecting muscle function.
The association between viral infections and myopathies is not fully understood.

Observation:

A 23-year-old woman presented with severe myalgias (muscle pain).
She had concurrent mild hepatitis B surface antigen-positive hepatitis.
Muscle biopsy revealed numerous microvacuoles containing neutral lipids.

Findings:

The patient's muscle carnitine levels were normal, ruling out carnitine deficiency.
Prednisone therapy led to complete resolution of myalgias and hepatitis.
This suggests a non-carnitine-deficient lipid storage myopathy induced by HBV.

Implications:

Hepatitis B virus infection can trigger a distinct form of lipid storage myopathy.
This case highlights the potential for viral infections to induce metabolic myopathies.
Further research is warranted to elucidate the pathogenic mechanisms involved.