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Related Experiment Videos

Insulin-induced renal dysfunction in regular Sabra rats

M Bursztyn1, D Ben-Ishay, J Mekler

  • 1Hypertension Unit, Department of Medicine, Hadassah University Hospital, Mount Scopus, Israel.

Clinical and Experimental Pharmacology & Physiology. Supplement
|January 1, 1995
PubMed
Summary

Chronic hyperinsulinaemia (high insulin levels) led to subtle but significant kidney dysfunction in rats. This may explain kidney complications in diabetes and hypertension.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Physiology

Background:

  • Hyperinsulinaemia is a condition characterized by elevated insulin levels.
  • Insulin resistance and hyperinsulinaemia are key features of conditions like diabetes mellitus and hypertension.
  • The direct impact of sustained hyperinsulinaemia on renal function requires further elucidation.

Purpose of the Study:

  • To investigate the effects of chronic hyperinsulinaemia on renal function in a rat model.
  • To determine if sustained high insulin levels impair kidney function under various physiological conditions.

Main Methods:

  • Sustained-release insulin implants were used to induce hyperinsulinaemia (1.5-4 times control levels) in rats.
  • Three experimental settings were employed: acute saline loading, chronic saline loading, and a regular diet.

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  • Renal function was assessed by measuring urea and creatinine excretion, plasma creatinine levels, and creatinine clearance.

    • Main Results:

    • Acute saline loading showed significantly lower urea and creatinine excretion in hyperinsulinaemic rats compared to controls.
    • Chronic saline loading resulted in higher plasma creatinine and lower creatinine clearance in insulin-treated rats by week 10.
    • On a regular diet, hyperinsulinaemic rats exhibited significantly elevated plasma creatinine and reduced creatinine clearance by week 8.
    • Bodyweight, blood pressure, and urinary electrolyte excretion remained comparable between groups.

    Conclusions:

    • Long-term hyperinsulinaemia is associated with subtle yet significant renal dysfunction across different experimental conditions.
    • These findings suggest a potential link between hyperinsulinaemia and the development of renal complications in diseases like hypertension and diabetes mellitus.