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Signalling pathway of GH

C Carter-Su1, A P King, L S Argetsinger

  • 1Department of Physiology, University of Michigan Medical School, Ann Arbor 48109-0622, USA.

Endocrine Journal
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

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Growth hormone (GH) cellular signaling involves JAK2 activation and downstream protein phosphorylation, including STATs, IRS, and Shc proteins. Glucocorticoids inhibit GH signaling by reducing GH receptor numbers.

Area of Science:

  • Cellular signaling pathways
  • Molecular endocrinology
  • Protein phosphorylation cascades

Background:

  • Growth hormone (GH) regulates body growth and metabolism, but its cellular mechanisms were unclear.
  • Understanding GH's molecular action is crucial for its therapeutic applications.

Purpose of the Study:

  • To elucidate the cellular mechanism of GH action.
  • To identify key signaling molecules and pathways activated by GH.
  • To investigate the specificity of GH signaling and potential modulators.

Main Methods:

  • Investigated GH receptor association with Janus kinase 2 (JAK2).
  • Analyzed tyrosine phosphorylation of JAK2 and GH receptor.
  • Identified downstream signaling proteins (STATs, IRS, Shc) using GH receptor/JAK2 complexes.

Related Experiment Videos

  • Examined the effect of glucocorticoids on GH signaling and GH receptor expression.

    • Main Results:

    • GH rapidly associates with and activates JAK2, leading to tyrosine phosphorylation.
    • Activated JAK2 phosphorylates STATs, IRS, and Shc proteins, mediating GH effects.
    • Glucocorticoids selectively inhibit GH signaling by reducing plasma membrane GH receptors.
    • Specific regions of the GH receptor are involved in glucocorticoid inhibition.

    Conclusions:

    • GH signaling is initiated by JAK2 activation, leading to a cascade of protein phosphorylations.
    • STATs, IRS, and Shc proteins are key mediators of GH's diverse cellular effects.
    • Glucocorticoids offer a mechanism to modulate GH signaling, with therapeutic implications.