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Human vasal changes after vasectomy: in vitro studies
G M Ghoniem1, M S Shoukry, A A Fayed
1Department of Urology, Alexandria University Medical School, Alexandria, Egypt.
Unlabelled:
Failure to impregnate, after successful vasovasostomy, has been attributed to immunologic, testicular, and epididymal factors.
Objectives:
To study the effect of vasectomy on human vas innervation and vesicoelastic properties.
Methods:
Vas rings were obtained from 8 healthy males during vasectomy as controls and compared to those of 3 vasovasostomy patients. The active and passive properties were determined and the cumulative blocking effects of phenoxybenzamine, propranolol, atropine and tetrodotoxin were studied.
Results:
There was significantly higher rigidity in the vasovasostomy group as compared to the control group but there were similar active forces between the two groups up to 100-120% of stretch. In the control group, phenoxybenzamine blocked 33.3%, propranolol blocked 15.8%, and atropine blocked 36.5% but tetrodotoxin had no further effect. In the vasovasostomy group, phenoxybenzamine blocked 33.3% (similar to control), propranolol blocked 2%, atropine blocked 11.7% and tetrodotoxin blocked 37.1%.
Conclusions:
In vasovasostomy group there was increased rigidity without reduction of the active force. There were also decreased cholinergic and possible existence of nonadrenergic noncholinergic neurotransmitters.
