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Human vasal changes after vasectomy: in vitro studies

G M Ghoniem1, M S Shoukry, A A Fayed

  • 1Department of Urology, Alexandria University Medical School, Alexandria, Egypt.

European Urology
|January 1, 1997
PubMed
Summary
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Vasectomy alters vas deferens properties, increasing rigidity and potentially affecting nerve signaling. This research sheds light on factors impacting fertility after vasectomy reversal.

Area of Science:

  • Urology
  • Reproductive Medicine
  • Surgical Research

Background:

  • Infertility post-vasovasostomy can stem from immunologic, testicular, or epididymal issues.
  • Understanding changes in the vas deferens after vasectomy is crucial for reproductive health.

Purpose of the Study:

  • To investigate the impact of vasectomy on human vas deferens innervation.
  • To assess the effect of vasectomy on the viscoelastic properties of the vas deferens.

Main Methods:

  • Vas rings from 8 healthy males undergoing vasectomy (controls) and 3 vasovasostomy patients were analyzed.
  • Active and passive properties of vas rings were determined.
  • The effects of phenoxybenzamine, propranolol, atropine, and tetrodotoxin were evaluated.

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Main Results:

  • Vasovasostomy patients exhibited significantly higher vas deferens rigidity compared to controls.
  • Active forces were similar between groups up to 120% stretch.
  • Pharmacological analysis revealed reduced responsiveness to propranolol and atropine, and increased sensitivity to tetrodotoxin in the vasovasostomy group.

Conclusions:

  • Vasovasostomy leads to increased vas deferens rigidity without compromising active force.
  • Evidence suggests decreased cholinergic neurotransmission and the presence of non-adrenergic, non-cholinergic neurotransmitters post-vasovasostomy.
  • These findings may explain some cases of failed impregnation after vasectomy reversal.