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Maternal circulation in the first-trimester human placenta--myth or reality?
R Jaffe1, E Jauniaux, J Hustin
1Department of Obstetrics and Gynecology, University of Rochester, NY 14642, USA.
American Journal of Obstetrics and Gynecology
|March 1, 1997
Summary
Maternal blood flow to the intervillous space is not established until late first trimester, contrary to classic theory. This finding impacts understanding of early pregnancy development and complications.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Developmental Biology
Background:
- The established theory posits high-pressure maternal blood flow into the intervillous space from early first trimester.
- Recent evidence challenges this, suggesting a delayed establishment of uteroplacental circulation.