[Effect of the tissue-specific lung adhesive factor on the urethane induction of pulmonary adenomas in mice]

The effect of adhesive factor (AF), urethane and their combination on the mechanical properties of lung tissue (this effect was assessed by the nuclei isolation during a standard dispersion procedure) and on adenoma induction was studied. As shown, the AF doses eliminating the primary action of urethane on the mechanical properties of the tissue significantly decreased the incidence of adenomas. High AF doses producing a contrary effect on the mechanical properties of the tissue failed to eliminate the primary effect of urethane and did not decrease the number of adenomas induced by urethane.