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Published on: July 17, 2016

Increased tendency to spontaneous in-vitro lymphocyte transformation in clinically active multiple sclerosis

K B Fraser, M Haire, J H Millar

    Lancet (London, England)
    |October 6, 1979
    PubMed

    Lymphocytes from 8 of 10 patients with clinically active multiple sclerosis (MS) but from only 3 of 18 patients with quiescent MS and 4 of 20 healthy donors transformed spontaneously on in-vitro culture. The transformed cells from all donors had the characteristics of B lymphocytes (surface and intracytoplasmic immunoglobulin and complement receptors) and carried antigens of Epstein-Barr virus. It is suggested that these results are further evidence that immunoregulation in active MS is abnormal.

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