Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The DIAB-HYCAR Study

P Passa1, G Chatellier

  • 1Diabetes Department, Saint Louis Hospital, Paris, France.

Diabetologia
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

This study investigated if low-dose ramipril reduces cardiovascular events in non-insulin-dependent diabetic patients with albuminuria. Results are pending, but the trial aims to clarify ACE inhibition benefits beyond blood pressure control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients With <i>Staphylococcus aureus</i> Bacteremia.

Open forum infectious diseases·2026
Same author

Amputation-free survival in the long-term follow-up and gender-related characteristics in patients revascularized for critical limb ischemia.

Journal de medecine vasculaire·2023
Same author

Peri-procedural complications following endovascular revascularization for critical limb ischemia.

Journal de medecine vasculaire·2022
Same author

Factors associated with psychological symptoms in hospital workers of a French hospital during the COVID-19 pandemic: Lessons from the first wave.

PloS one·2022
Same author

Patients with atherosclerotic peripheral arterial disease have a high risk of lung cancer: Systematic review and meta-analysis of literature.

Journal de medecine vasculaire·2021
Same author

Influence of clinical suspicion on CT accuracy of acute mesenteric ischemia: Retrospective study of 362 patients.

European journal of radiology·2021
Same journal

Baseline and longitudinal joint associations of alcohol consumption and obesity with diabetes risk: evaluating multiplicative and additive interactions.

Diabetologia·2026
Same journal

GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study.

Diabetologia·2026
Same journal

Correction: Analysis of glycaemic control with a connected smart pen cap in adults with type 1 diabetes: a randomised, open-label, parallel-group trial.

Diabetologia·2026
Same journal

History of infertility, risk of type 2 diabetes and HbA<sub>1c</sub> levels in the Nurses' Health Study II.

Diabetologia·2026
Same journal

Delayed maturation of the milk microbiome in women with type 1 diabetes.

Diabetologia·2026
Same journal

Remodelling of body composition surrounding the diagnosis of type 2 diabetes in three longitudinal cohorts.

Diabetologia·2026
See all related articles

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Microalbuminuria and proteinuria predict cardiovascular mortality in non-insulin-dependent diabetic (NIDDM) patients.
  • Angiotensin-converting enzyme (ACE) inhibition benefits diabetic nephropathy but its cardiovascular impact in NIDDM is unknown.

Purpose of the Study:

  • To test if low-dose ramipril (1.25 mg daily), without significant blood pressure effect, reduces cardiovascular morbidity/mortality in NIDDM patients with persistent albuminuria.
  • To evaluate ACE inhibition's role in cardiovascular risk reduction in this specific diabetic population.

Main Methods:

  • Randomized, double-blind, placebo-controlled trial involving 4000 NIDDM patients.
  • Patients receive standard care plus either placebo or 1.25 mg ramipril daily for 3 years.

Related Experiment Videos

  • Major endpoints include cardiovascular death, sudden death, myocardial infarction, stroke, and renal replacement therapy.

    • Main Results:

    • Study initiated February 1995, with initial screening identifying 23% prevalence of persistent albuminuria.
    • 964 patients initially included, with 619 eligible patients enrolled shortly after.
    • Data collection strategies are in place to accurately record cardiovascular events and minimize patient loss to follow-up.

    Conclusions:

    • The Diab-Hycar study is designed to provide crucial data on the cardiovascular protective effects of low-dose ACE inhibition in NIDDM patients with albuminuria.
    • Findings will inform clinical practice regarding the management of cardiovascular risk in this vulnerable patient group.