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[Amiodarone pigmentation]

R Ammann1, L R Braathen

  • 1Dermatologische Universitätsklinik, Inselspital Bern.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|December 1, 1996
PubMed
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Amiodarone, an antiarrhythmic drug, can cause slate-colored skin pigmentation, especially on UV-exposed areas. This drug-induced pigmentation is linked to dose and duration, but may resolve after discontinuing amiodarone.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Amiodarone is an antiarrhythmic medication.
  • Chronic use can lead to photosensitivity and skin changes.

Observation:

  • A 63-year-old patient developed pruritic, bluish-purple facial pigmentation after 2 years of daily amiodarone therapy.
  • The pigmentation persisted unchanged for 24 months after reducing the amiodarone dose.

Findings:

  • Amiodarone-induced skin pigmentation results from UV-induced lipofuscin accumulation in dermal macrophages.
  • Pigmentation severity correlates with amiodarone's daily dose and treatment duration.
  • Other drug-induced pigmentations are key considerations in differential diagnosis.

Implications:

  • Discontinuation of amiodarone therapy can lead to complete resolution of skin pigmentation.

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  • Awareness of this side effect is crucial for clinicians managing patients on long-term amiodarone.
  • Further research into the precise mechanisms and management strategies for amiodarone-induced pigmentation is warranted.