Related Experiment Videos
Hepatotoxicity after a short course of low-dose pyrazinamide
K A al Sarraf1, P P Michielsen, E I Hauben
1Division of Gastroenterology, University of Antwerp (U.I.A.), Belgium.
Acta Gastro-Enterologica Belgica
|October 1, 1996
Abstract:
We report on a patient who developed extensive centrolobular liver necrosis after a treatment with low-dose (25 mg/kg/d) pyrazinamide for only 4 weeks, combined with rifampicin, 600 mg/d). In the past, the patient already developed severe aminotransferase elevations under isoniazid treatment. After prompt withdrawal of the drugs, a gradual decline of the aminotransferases was observed. No signs of hepatic failure developed. Pyrazinamide has to be used with caution, even in low-dose, especially when combined with rifampicin.