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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

RespiGam: an RSV immune globulin

M D Oertel1

  • 1University of North Carolina Hospitals, Department of Pharmacy, in Chapel Hill, USA.

Pediatric Nursing
|November 1, 1996
PubMed

Insights

Respiratory syncytial virus immune globulin (RSV-IG) effectively prevents lower respiratory tract infections in high-risk infants. However, its high cost necessitates careful consideration for eligible candidates.

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants.
  • Infants with bronchopulmonary dysplasia (BPD) or born prematurely (<35 weeks gestation) are at higher risk for severe RSV disease.
  • RSV immune globulin (RSV-IG) prophylaxis is available to reduce RSV-related morbidity in these vulnerable infants.

Purpose of the Study:

  • To evaluate the efficacy of RSV-IG in preventing or attenuating RSV lower respiratory tract infections.
  • To discuss the cost-effectiveness and appropriate use of RSV-IG in eligible infant populations.

Main Methods:

  • Review of existing clinical data on RSV-IG efficacy in infants with BPD or prematurity.
  • Analysis of the economic implications of seasonal RSV-IG prophylaxis.

Main Results:

  • RSV-IG has demonstrated effectiveness in preventing or reducing the severity of RSV lower respiratory tract infections in infants under 24 months with BPD or born prematurely.
  • The estimated cost for seasonal prophylaxis ranges from $4,000 to $5,000 per infant.

Conclusions:

  • RSV-IG is a valuable tool for protecting high-risk infants from severe RSV disease.
  • The significant cost of RSV-IG, coupled with the potential risks associated with blood products, warrants careful patient selection for prophylaxis.

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