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Magnetic resonance urography by breath-hold contrast-enhanced three-dimensional FISP
1Department of Radiology, Beth Israel Hospital, Boston, MA, USA.
Abstract:
The purpose of this study was to present our initial experience with contrast-enhanced MR urography with a breath-hold three-dimensional imaging technique. We performed MR urographic studies in two pigs (four studies) and five human subjects using gadopentetate dimeglumine. The FISP sequence we used was the same as the one used for contrast-enhanced three-dimensional breath-hold angiography. MR three-dimensional urograms were obtained 7-24 minutes after the contrast injection with a dose as low as .03 mmol/kg. The calyces, renal pelves, and ureters were very well visualized. Three-dimensional MR urography can be acquired within a single breath-hold after administration of gadolinium chelates. This technique could become part of a protocol that could potentially lead to a single comprehensive diagnostic workup for suspected ureteral obstruction and gross hematuria.
Insights
Contrast-enhanced Magnetic Resonance (MR) urography offers excellent visualization of the urinary tract. This breath-hold 3D technique shows potential for diagnosing ureteral obstruction and hematuria.
Area of Science:
- Radiology
- Medical Imaging
- Urology
Background:
- Magnetic Resonance (MR) urography is an imaging technique used to visualize the urinary tract.
- Conventional MR urography may require longer scan times and patient cooperation.
- Developing faster, more efficient MR urography techniques is crucial for clinical application.
Purpose of the Study:
- To evaluate the initial experience with a novel contrast-enhanced, breath-hold, three-dimensional (3D) MR urography technique.
- To assess the feasibility and image quality of this technique in both animal models and human subjects.
Main Methods:
- Utilized a breath-hold 3D imaging sequence (FISP) for contrast-enhanced MR urography.
- Administered gadopentetate dimeglumine contrast agent at a low dose (.03 mmol/kg).
- Acquired MR urographic data in two pigs and five human subjects, with imaging performed 7-24 minutes post-injection.
Main Results:
- The contrast-enhanced 3D MR urography technique provided excellent visualization of the calyces, renal pelves, and ureters.
- High-quality MR urograms were successfully obtained within a single breath-hold period.
- The technique demonstrated feasibility in both animal and human studies.
Conclusions:
- Three-dimensional contrast-enhanced MR urography is a rapid and effective technique for visualizing the urinary tract.
- This method can be performed within a single breath-hold after gadolinium chelate administration.
- The technique holds promise as a component of a comprehensive diagnostic workup for conditions like ureteral obstruction and gross hematuria.