Practice patterns among reproductive endocrinologists: the infertility evaluation
Related Experiment Video
Updated: Nov 2, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
I Z Glatstein1, B L Harlow, M D Hornstein
1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Objective:
To determine how board-certified reproductive endocrinologists vary in their approach to the clinical tests performed on the infertile couple.
Design:
A cross-sectional study to assess differences in the approach to evaluating the infertile couple.
Setting:
A population-based national survey.
Participant(S):
United States board-certified reproductive endocrinologists.
Main Outcome Measure(S):
The frequency of clinical tests and evaluation procedures by physician age, sex, size and setting of practice, institutional affiliation, and geographic location.
Result(S):
The overall response rate was 84%. Although the majority of practitioners routinely order a semen analysis (99.9%), an assessment of ovulation (98%), a hysterosalpingogram, (HSG; 96%), laparoscopy (89%), and a postcoital test (PCT, 79%), there was less agreement regarding hormonal testing (range, 22% [LH] to 66% [PRL]), use of pelvic ultrasounds (55%), hysteroscopy (53%), cervical cultures (range, 24% to 54%), and antisperm antibody testing (24%). Compared with male colleagues, female physicians order two to three times more cervical cultures and endometrial biopsies. Serum hormonal testing was two to three times more commonly ordered by younger (< 40 years) compared with older physicians, and physicians in private practice twice as frequently ordered hormonal testing, cervical cultures, PCTs, and antisperm antibody studies compared with their academic-affiliated colleagues. Western U.S. physicians order hormonal tests and cervical cultures 50% less often than their midwest and eastern counterparts.
Conclusion(S):
Trained specialists rely heavily on five "traditional" infertility tests: semen analysis, an assessment of ovulation, HSG, laparoscopy, and PCT. With regard to additional modes of testing, there is marked variability by physician sex, age, type of practice, and geographic location.
Related Concept Videos
Infertility in Males
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of endometrial...
In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Overview of the Reproductive System
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
