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Pregnancy rates using CC/hMG or hMG alone
S M Ziadeh1, M R Zakaria, A Abu-Hieja
1Department of Obstetrics and Gynaecology, Jordan University of Science and Technology, Irbid, Jordan.
The Journal of Obstetrics and Gynaecology Research
|February 1, 1997
Summary
Clomiphene citrate (CC) plus human menopausal gonadotrophin (hMG) significantly improved conception rates in infertile women compared to hMG alone. This combination therapy offers a safe and effective treatment for infertility.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatment
- Assisted Reproductive Technologies
Background:
- Primary infertility affects a significant number of couples seeking conception.
- Ovulation induction is a key component in managing infertility.
- Comparing different drug regimens is crucial for optimizing treatment outcomes.
Purpose of the Study:
- To compare the efficacy of two drug regimens for achieving conception in infertile couples.
- To determine the superior treatment protocol for ovulation induction.
Main Methods:
- A retrospective study involving 160 women with primary infertility.
- Group A (102 patients) received clomiphene citrate (CC) and human menopausal gonadotrophin (hMG).
- Group B (58 patients) received hMG alone, with ovulation monitored by ultrasound and serum E2.
Main Results:
- Group A demonstrated a higher pregnancy rate per patient (46% vs. 25.9%) and per cycle (31.3% vs. 15.8%) compared to Group B.
- Pregnancy loss was lower in Group A (17% vs. 33.3%).
- Incidence of multiple pregnancies and ovarian hyperstimulation syndrome was comparable or lower in Group A.
Conclusions:
- The combination of CC + hMG is more successful in achieving conception than hMG alone.
- CC + hMG is a safe and effective method for treating infertile patients within an assisted conception program.
- Ultrasound and serum E2 monitoring enhance the success of ovulation induction protocols.