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Pattern of retinal dysfunction in acute zonal occult outer retinopathy
S G Jacobson1, D S Morales, X K Sun
1Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, USA.
Ophthalmology
|August 1, 1995
Summary
Acute zonal occult outer retinopathy (AZOOR) involves photoreceptor dysfunction that is patchy and asymmetric between eyes. Full-field electroretinograms (ERGs) aid diagnosis, but no specific autoantibodies were found.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neuro-ophthalmology
Background:
- Acute zonal occult outer retinopathy (AZOOR) is a grouping of distinct retinal conditions.
- Understanding the underlying pathophysiology of AZOOR is crucial for diagnosis and management.
Purpose of the Study:
- To elucidate the pathophysiology of diseases classified under acute zonal occult outer retinopathy (AZOOR).
Main Methods:
- Evaluated 24 patients diagnosed with various white dot syndromes or related conditions using full-field electroretinograms (ERGs) and perimetry.
- Tested patient sera and IgG fractions for autoantibodies against retinal tissues using immunofluorescence.
Main Results:
- Patients with AZOOR exhibited abnormal ERGs and visual field parameters, with prominent interocular asymmetry.
- Interocular ERG differences significantly improved AZOOR identification. Visual field area correlated with ERG a-wave amplitude.
- Serial testing revealed potential for partial recovery or progressive visual function loss; no specific autoantibodies were detected.
Conclusions:
- AZOOR presents as photoreceptor dysfunction, patchy and asymmetric between eyes.
- Full-field ERG is a valuable diagnostic tool for AZOOR, considering interocular variations.
- No evidence of autoantibodies against retinal cells was found in the studied AZOOR patients.