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10:28
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
Bromocriptine for cocaine dependence. A controlled clinical trial
L Handelsman1, A Rosenblum, M Palij
1Mt. Sinai School of Medicine, New York, NY 10029, USA.
The American Journal on Addictions
|January 1, 1997
Summary
Bromocriptine did not effectively reduce cocaine dependence or craving in a clinical trial. This study found no significant difference between bromocriptine and placebo for cocaine users.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Pharmacology
Background:
- The dopamine depletion theory suggests bromocriptine may treat cocaine dependence.
- Previous pilot studies indicated potential efficacy.
Purpose of the Study:
- To evaluate bromocriptine's efficacy in treating cocaine dependence and withdrawal symptoms.
- To assess the impact of bromocriptine on cocaine use, craving, and mood.
Main Methods:
- A 6-week randomized, double-blind, placebo-controlled trial was conducted.
- Participants were methadone-maintained male patients with DSM-III-R-defined cocaine dependence.
- Outcomes measured included self-reported cocaine use, urine toxicology, craving, and mood.
Main Results:
- No significant differences were observed between the bromocriptine and placebo groups.
- Both groups showed reductions in cocaine use frequency and craving.
- No significant improvements in mood symptoms were noted for bromocriptine.
Conclusions:
- Bromocriptine is not effective in reducing cocaine use or craving in this patient population.
- Current evidence does not support bromocriptine's efficacy for cocaine dependence.
- Further research may be needed to explore alternative treatments.
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