Related Experiment Videos
Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis
C Vandevyver1, P Raus, P Stinissen
1Department of Immunology/Biotechnology, Dr L. Willems-Institut, Diepenbeek, Belgium.
Abstract:
We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not significantly different in the patient populations, compared to controls. An increased frequency of the TNF-beta*2 allele was observed in HLA-DR2+ vs. HLA-DR2- MS patients. No such association was seen in HLA-DR4+ RA patients.