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HLA class II region nucleotide sequences, 1994

S G Marsh¹, J G Bodmer

¹Tissue Antigen Laboratory, Imperial Cancer Research Fund, London, UK.

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics

|December 1, 1994

Summary

This compilation presents Human Leukocyte Antigen (HLA) class II region sequences, ensuring accuracy through author consultation and incorporating amendments. It details sequence alignment methods, including symbols for identity, unavailability, and gaps, to manage variations across alleles.

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Area of Science:

Immunogenetics
Molecular Biology
Genomics

Background:

The Human Leukocyte Antigen (HLA) system is crucial for immune response.
Accurate HLA class II region sequences are essential for research and clinical applications.
Previous compilations of HLA sequences have relied on published data.

Purpose of the Study:

To compile and present accurate Human Leukocyte Antigen (HLA) class II region sequences.
To resolve discrepancies in reported sequences by contacting original authors.
To establish a reliable reference for HLA class II allele sequences.

Main Methods:

Sequence data was gathered from established "Nomenclature for factors of the HLA system" publications.
Discrepancies in reported sequences were addressed through direct communication with original authors.

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Sequence alignments were generated, using symbols for identity (-), unavailable sequences (*), and gaps.

Main Results:

A comprehensive compilation of HLA class II region sequences has been established.
Amendments to published sequences were incorporated based on author feedback.
Sequence alignments were formatted to accommodate variations in amino acid numbering and allele completeness.

Conclusions:

The compiled HLA class II sequences provide an updated and more accurate resource.
Ongoing efforts to maintain accuracy through future evidence are welcomed.
The alignment methodology facilitates the comparison of diverse HLA alleles.