Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat
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C S Cobbs1, A Fenoy, D S Bredt
1Department of Neurosurgery, University of California and San Francisco General Hospital, 94110, USA.
Brain Research
|March 21, 1997
Abstract:
Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.