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Anterior chamber concentrations of vancomycin in the irrigating solution at the end of cataract surgery
J P Adenis1, P Y Robert, M Mounier
1Service d'ophtalmologie, Université de Limoges, Faculté de Médecine, France.
Purpose:
To verify that therapeutic levels of vancomycin were present in the irrigating solution at the end of cataract surgery.
Setting:
Service d'ophtalmologie, Université de Limoges, France.
Methods:
An irrigating solution that contained 20 mg/L of vancomycin was used in 15 patients having phacoemulsification. Antibiotic concentrations in the phacoemulsification handpiece and in the aqueous humor were measured at the end of surgery.
Results:
Passage through the phacoemulsifier did not affect antibiotic concentration. In the aqueous humor, after wound closure, the concentration constantly exceeded the minimal inhibitory concentration of the principal gram-positive bacteria responsible for human endophthalmitis.
Conclusion:
Vancomycin added to the irrigating solution used during cataract surgery was found in effective concentrations in the anterior chamber at the end of surgery.