Clearance and dialysance of 3H-aldosterone in vitro

Using an "in vitro dialysis" with different dialyzers, a significant decrease in 3H-aldosterone concentration was seen. From the decrease of 3H aldosterone elimination parameters were calculated. Half time of elimination was 21,5 min, the mean clearance of all dialyzers averaged 32.2 ml/min. The dialysances of 3H aldosterone evaluated with dialyzers of different surface areas were correlated with the surface areas of the dialyzers. From the results can be concluded, that besides individual influences of regulation, haemodialysis influences aldosterone concentration in plasma by physical factors.