Changes in peripheral pulmonary vascular resistance after ioxaglate infusion in anesthetized dogs

The pulmonary vascular resistance in a peripheral portion of the pulmonary vascular bed can be determined with a catheter wedged in a peripheral branch of the pulmonary artery, from the pressure increase induced by infusion of mixed venous blood at known flow rates. The volume of the wedged vascular bed can be estimated during fluoroscopy, from the volume of a contrast agent infused until the corresponding pulmonary vein can be seen. The present work was undertaken to determine the possible influence of this maneuver on the peripheral pulmonary vascular resistance (PPVR). In anesthetized dogs, after a control flow run, Hexabrix (meglumine ioxaglate and sodium ioxaglate) was infused, then the catheter was flushed with saline, and another flow run was performed. There was no significant difference between two consecutive control runs in the same site (n = 14). Before Hexabrix (n = 23), PPVR was 162 (+/-24) x 10(3) dyn.s.cm-5 (1 dyn = 10 microN) during the control run; it increased to 339 (+/-33) x 10(3) dyn.s.cm-5 after Hexabrix (p < 0.001). These results show that care should be taken to avoid interference between Hexabrix and the results of physiological or pharmacological interventions with this technique.