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Prognostic factors of prenatally diagnosed gastroschisis
D Luton1, P De Lagausie, J Guibourdenche
1Département de Périnatalogie, Hôpital Robert-Debré, Paris, France.
Objective:
To evaluate the prognosis of prenatally diagnosed gastroschisis.
Study Design:
In a retrospective study, we analyzed the clinical and echographic data of gastroschisis. These data were correlated with fetal outcome including delivery, surgical procedure, follow-up in the neonatal intensive-case unit and in the gastropediatric unit.
Result:
Twenty cases were analyzed. The overall survival rate was 85%. Classical criteria were analyzed (maximal bowel dilatation, thickening of bowel wall). Fetuses with both severe perivisceritis and meconium-stained amniotic fluid were born earlier than fetuses with mild perivisceritis and normal amniotic fluid (p < 0.01).
Conclusion:
Our data suggest that an inflammatory response could follow bowel exposure to amniotic fluid. This response could lead to perivisceritis and premature birth. This hypothesis is currently under investigation.