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Related Experiment Videos

Maternal prolactin secretion is phasic during induced term and post-term labor

P A Fernandes1, S R Koodoo, A M Wodzicki

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Women's Hospital, Winnipeg, Canada.

Journal of the Society for Gynecologic Investigation
|March 1, 1997
PubMed
Summary

Maternal prolactin (PRL) secretion follows a biphasic pattern during induced labor, decreasing in the first stage and increasing in the second. This pattern is consistent across various labor induction methods.

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Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine

Background:

  • Spontaneous labor is characterized by a biphasic secretion pattern of maternal prolactin (PRL).
  • Understanding hormonal changes during labor is crucial for managing pregnancy and delivery.

Purpose of the Study:

  • To investigate whether different labor induction regimens alter the biphasic secretion of maternal prolactin (PRL) observed during spontaneous labor.

Main Methods:

  • Serial blood samples were collected from 12 women undergoing induced labor.
  • Samples were analyzed for PRL and human chorionic gonadotropin (hCG) levels.
  • Data were correlated with cervical dilatation and uterine contraction frequency (UCF).

Main Results:

  • Maternal PRL levels decreased during the first stage of labor, reaching a minimum at full dilatation.

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  • PRL levels increased significantly during the second stage, correlating with uterine contraction frequency.
  • Human chorionic gonadotropin (hCG) levels rose during labor, peaking around delivery.

    • Conclusions:

    • The biphasic secretion pattern of maternal PRL is a fundamental aspect of active term labor.
    • This hormonal pattern persists irrespective of the method employed for labor induction.