Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute ureteral obstruction and glomerulotubular function in rats

E P Dias1, W E Garcia, J R Gontijo

  • 1Departamento de Clinica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil.

Renal Failure
|March 1, 1997
PubMed
Summary

Unilateral ureteral obstruction (UUO) impairs kidney function, but deobstruction leads to a significant increase in glomerular filtration rate (GFR) after seven days. This suggests a potential for kidney recovery and even overcorrection following obstruction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue.

Journal of the European Academy of Dermatology and Venereology : JEADV·2014
Same author

Environmental factors in benign migratory glossitis and psoriasis: retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2014
Same author

Prevalence of oral manifestations in 203 patients with psoriasis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2010
Same author

Morphologic and cytokine profile characterization of Salmonella enterica serovar typhimurium infection in calves with bovine leukocyte adhesion deficiency.

Veterinary pathology·2010
Same author

Early phase morphological lesions and transcriptional responses of bovine ileum infected with Mycobacterium avium subsp. paratuberculosis.

Veterinary pathology·2009
Same author

Actin cytoskeletal and functional studies of the proximal convoluted tubules after preservation.

Transplantation proceedings·2008

Area of Science:

  • Nephrology
  • Renal Physiology
  • Urology

Background:

  • Urinary tract obstruction is a common cause of acute renal failure.
  • Unilateral ureteral obstruction (UUO) involves vasoconstriction, increased tubular pressure, and ultrafiltrate retrodiffusion.

Purpose of the Study:

  • To investigate renal functional recovery after deobstruction of unilateral ureteral obstruction (UUO).
  • To analyze changes in glomerular filtration rate (GFR) and tubular sodium handling post-UUO deobstruction.

Main Methods:

  • Surgical UUO in rats for 24 hours, followed by contralateral nephrectomy and ureteral deobstruction.
  • Measurement of creatinine clearance, fractional sodium and lithium excretion, and calculated fractional sodium reabsorption at 12, 24 hours, and 7 days post-deobstruction.
  • Comparison with a control group undergoing uninephrectomy only.

Related Experiment Videos

Main Results:

  • Initial reduction in GFR post-deobstruction, followed by a significant increase (overcorrection) at 7 days compared to controls.
  • Increased fractional sodium excretion and decreased fractional distal sodium reabsorption in deobstructed rats.
  • Increased kidney weight observed in deobstructed rats after 7 days.

Conclusions:

  • UUO significantly impacts both glomerular and tubular renal functions.
  • Deobstruction leads to a notable overcorrection of GFR, indicating adaptive mechanisms.
  • Renal hormones and growth factors likely mediate these functional and proliferative changes post-obstruction.