[An experimental study of the hemostatic system in acute radiation sickness exacerbated by skin burns]

The experiments on Wistar rats and mice (C57B16)F1 exposed to gamma irradiation at the doses of 4,5 to 7,5 Gy, alone and in combination with a III-B skin burn of 10-30% skin surface, showed that a combined injury results in a higher death rate. On a background of the bone marrow hemocytogenesis depression, a syndrome of disseminated intravascular blood coagulation and the irradiation-induced hemorrhagic syndrome develop. It was shown that the bone marrow depression and hemostasis disorders play an important role in the thanatogenesis of a combined radiation and thermal injury. The problems of diagnosis and therapy are discussed.