Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Proteoglycans and pathology--new aspects]

S O Kolset1, C A Drevon, K Prydz

  • 1Institutt for ernaeringsforskning, Universitetet i Oslo, Blindern.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|March 10, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults.

Mechanisms of ageing and development·2025
Same author

Maternal body mass index and placental weight: a role for fetal insulin, maternal insulin and leptin.

Journal of endocrinological investigation·2022
Same author

Adherence to the Healthy Nordic Food Index and the incidence of acute myocardial infarction and mortality among patients with stable angina pectoris.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2018
Same author

Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain").

European psychiatry : the journal of the Association of European Psychiatrists·2017
Same author

Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines.

Molecular metabolism·2017
Same author

Biomarkers for nutrient intake with focus on alternative sampling techniques.

Genes & nutrition·2016

Proteoglycans play a role in various diseases. New research links proteoglycan gene mutations to overgrowth syndromes and identifies a urine proteoglycan that induces cancer cachexia.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Context:

  • Proteoglycans are crucial extracellular matrix components implicated in numerous pathological conditions.
  • Recent studies have elucidated novel roles for proteoglycans in disease pathogenesis.

Purpose:

  • To highlight recent findings on the involvement of proteoglycans in specific pathological conditions.
  • To underscore the diagnostic and therapeutic potential of understanding proteoglycan function in disease.

Summary:

  • A mutation in a cell surface proteoglycan gene is associated with overgrowth syndromes.
  • A urinary proteoglycan has been identified as a potential inducer of cancer cachexia.
  • Genetic defects in sulfate transporters impair proteoglycan sulfation in achondrogenesis and colon cancer, while decorin gene transfer inhibits fibrosis in glomerulonephritis models.

Related Experiment Videos

Impact:

  • These findings expand our understanding of proteoglycan involvement in genetic disorders, cancer, and fibrotic diseases.
  • The research suggests potential therapeutic strategies targeting proteoglycan function and associated genetic defects.