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Carborundum, a bulk similar to dietary fibers but chemically inert, does not decrease colon carcinogenesis

D E Corpet1, S Taché, G Peiffer

  • 1Ecole Nationale Vétérinaire, Laboratoire de Sécurité des Aliments, Institut National de la Recherche Agronomique, Toulouse, France.

Cancer Letters
|March 19, 1997
PubMed
Summary

This study investigated if inert bulk, like dietary fiber, prevents colon cancer. Results showed that while carborundum increased fecal weight, it did not reduce aberrant crypt foci, suggesting inert bulk doesn't protect against colon cancer.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Toxicology

Background:

  • Dietary fibers are hypothesized to reduce colorectal cancer risk.
  • A potential mechanism involves a 'bulking effect' that dilutes carcinogens.
  • This study examines if an inert bulk agent can replicate this protective effect.

Purpose of the Study:

  • To test the hypothesis that an inert bulk can protect against azoxymethane-induced colon carcinogenesis in rats.
  • To determine if increasing fecal bulk with carborundum influences the development of aberrant crypt foci.

Main Methods:

  • Thirty rats were injected with azoxymethane to induce carcinogenesis.
  • Rats were divided into two groups: a control diet and a diet supplemented with 10% carborundum.
  • Colons were analyzed after 100 days for aberrant crypt foci (ACF).

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Main Results:

  • Rats fed carborundum showed a significant increase in fecal weight (doubled) compared to controls (P < 0.001).
  • There was no significant difference in the multiplicity of aberrant crypt foci between the carborundum-fed group and the control group (P = 0.92).

Conclusions:

  • The findings do not support the hypothesis that intestinal dilution by an inert bulk agent protects against colon cancer.
  • The bulking effect of dietary components may not be the primary mechanism by which fiber prevents colorectal cancer.