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Biological reactors for renal support
Transactions - American Society for Artificial Internal Organs
|January 1, 1977
Summary
This study explores using specific microorganisms to treat chronic renal failure, aiming for more physiologic systems. Mixed microbial strains show promise in removing waste products, suggesting a potential alternative treatment.
Area of Science:
- Microbiology
- Nephrology
- Biotechnology
Background:
- Chronic renal failure (CRF) necessitates advanced treatment strategies.
- Current treatments for CRF have limitations.
- Physiologic treatment systems are needed for CRF management.
Purpose of the Study:
- To develop more physiologic treatment systems for chronic renal failure.
- To investigate the use of specific microbial strains for waste removal in CRF.
- To evaluate the efficiency of microorganisms in managing nitrogenous metabolites.
Main Methods:
- Selection of appropriate microorganisms based on nitrogenous metabolite removal efficiency.
- Utilizing batch reactors for microbial studies.
- Investigating mixed microbial strains and their interdependence.
Main Results:
- Microorganisms can remove significant quantities of nitrogenous metabolites.
- Removal times approximate the interdialytic period.
- Mixed microbial strains are required, with interdependence being beneficial.
Conclusions:
- The use of specific microbial strains shows potential for treating chronic renal failure.
- Further research will focus on in vivo applications and combination with other technologies.
- This microbial approach could offer an alternative treatment for CRF.