[Effect of diabetes therapy on the lipid parameters in blood]

In diabetics with different therapy indications the effect of the treatment on the lipid parameters of blood was examined. We estimated the change of the triglycerides, the cholesterol, the free fatty acids and the glycerol depending on the duration of the therapy. We used a combined stimulation test (combination of 100 g glucose, 1.0 g tolbutamide and 1.0 g glucagon in temporary coupling) as method for characterization of the type of diabetes. At the beginning of the therapy the fat parameters mentioned did not differ in patients with exclusively dietetic treatment and in SuH-patients. After longer duration of the therapy in exclusively dietetically compensated patients the fasting glycerol values decreased, were, however, statistically not significant. There were also no essential changes of the triglycerides, the cholesterol and the values of the free fatty acids in the two forms of treatment. The improvement of the carbohydrate tolerance could not be explained with changes of the insulin secretion. The results plead for the fact that the improvement of the diabetic metabolism develops by an increase of the peripheral insulin effectivity. The behaviour of the lipid parameters is not sufficient for an explanation of the carbohydrate tolerance.