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Essential trace element alterations in amyotrophic lateral sclerosis
E Kapaki1, C Zournas, G Kanias
1Department of Neurology (Research Laboratory), Athens National University, Eginition Hospital, Greece.
Journal of the Neurological Sciences
|April 15, 1997
Summary
Amyotrophic lateral sclerosis (ALS) patients show altered essential trace element levels. Copper levels were decreased in serum and cerebrospinal fluid, while manganese increased, indicating a significant trace element imbalance in ALS disease.
Area of Science:
- Neuroscience
- Biochemistry
- Clinical Chemistry
Background:
- Trace elements are implicated in amyotrophic lateral sclerosis (ALS) pathogenesis.
- Familial ALS links to copper-zinc superoxide dismutase, highlighting the importance of metalloenzyme metabolism studies.
Purpose of the Study:
- To investigate serum and cerebrospinal fluid levels of essential trace elements in ALS patients.
- To determine if copper, zinc, manganese, and magnesium levels differ between ALS patients and healthy controls.
Main Methods:
- Atomic absorption spectrophotometry was used to measure serum and cerebrospinal fluid trace element concentrations.
- Patient and control groups were compared for statistically significant differences in element levels.
Main Results:
- Significantly decreased serum and cerebrospinal fluid copper levels were observed in ALS patients compared to controls.
- Significantly increased serum manganese levels were found in ALS patients versus controls.
- Serum zinc and magnesium levels remained unchanged between groups.
Conclusions:
- Amyotrophic lateral sclerosis is associated with a notable imbalance of essential trace elements.
- Altered copper and manganese metabolism may play a role in ALS pathogenesis.
- Further research into trace element dysregulation in ALS is warranted.