Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomic polymorphism in herpes simplex virus keratitis

M J Martínez1, M Vogel, L Traipe

  • 1Department of Microbiology, School of Medicine, University of Chile, Santiago, Chile. martinez@machi.med.uchile.cl

Microbiologia (Madrid, Spain)
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Comparison of dalbavancin with standard of care in the management of infective endocarditis: efficacy, safety, and cost analysis" [International Journal of Infectious Diseases, Volume 138 (January 2024), Pages 41-45].

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

OUTPACE: Outcomes of urinary incontinence treatment in primary care - APP co-management and electronic consult.

Contemporary clinical trials·2025
Same author

Hospitalization determinants in patients with Mpox disease: The CEME-22 Project.

Heliyon·2024
Same author

Clinical and Epidemiological Characteristics of the 2022 Mpox Outbreak in Spain (CEME-22 Study).

Open forum infectious diseases·2024
Same author

Adaptation culturally and linguistically to the Chilean population and validation the Dry Eye Questionnaire 5.

Archivos de la Sociedad Espanola de Oftalmologia·2023
Same author

Stand-alone optical spinning tweezers with tunable rotation frequency.

Optics express·2023

Herpes simplex virus type 1 (HSV-1) causes serious eye infections like keratitis. This study identified nine distinct HSV-1 genomic variants in patients with acute herpetic epithelial keratitis, highlighting strain diversity.

Area of Science:

  • Ophthalmology
  • Virology
  • Genetics

Background:

  • Viral infections, particularly herpes simplex virus (HSV), are leading causes of infectious conjunctivitis and keratoconjunctivitis.
  • Herpes simplex virus type 1 (HSV-1) is a significant cause of infectious blindness and ocular lesions.
  • Genomic variability exists within HSV types, potentially influencing disease presentation.

Purpose of the Study:

  • To investigate the genomic diversity of herpes simplex virus type 1 (HSV-1) in patients with acute herpetic epithelial keratitis.
  • To identify specific HSV-1 genomic variants associated with ocular infections.

Main Methods:

  • Monoclonal antibodies were used for viral identification.
  • Restriction enzyme analysis was employed to differentiate HSV-1 genomic variants.

Related Experiment Videos

  • Twelve patients diagnosed with acute herpetic epithelial keratitis were analyzed.

    • Main Results:

    • Nine distinct genomic variants of HSV-1 were identified among the twelve patients studied.
    • The findings confirm the association of diverse HSV-1 strains with herpetic epithelial keratitis.
    • Specific viral genotypes may correlate with distinct ocular pathologies.

    Conclusions:

    • A significant variety of HSV-1 genomic strains are implicated in acute herpetic epithelial keratitis.
    • Understanding HSV-1 genomic diversity is crucial for diagnosing and managing ocular infections.
    • Further research into strain-specific virulence factors is warranted.