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PET imaging of maze processing

S Flitman1, J O'Grady, V Cooper

  • 1Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA.

Neuropsychologia
|April 1, 1997
PubMed
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This study investigated brain activity during maze navigation. Findings show that maze processing, particularly spatial planning and navigation, primarily engages the right hemisphere of the brain.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Maze traversal involves nonverbal planning and sequential execution of moves.
  • Learned spatial maps are crucial for navigating complex environments.
  • Understanding the neural basis of spatial navigation is essential for cognitive research.

Purpose of the Study:

  • To identify the neural substrates involved in covered and uncovered maze processing.
  • To investigate the lateralization of brain activity during spatial navigation tasks.
  • To explore the roles of specific brain regions in spatial planning and path information storage.

Main Methods:

  • Positron Emission Tomography (PET) with [H(2)15O] was used to measure brain activity.
  • Eleven healthy adults participated in the study.

Related Experiment Videos

  • Four conditions were tested: motor control, visual control, uncovered maze traversal, and covered maze traversal.

    • Main Results:

    • Maze processing demonstrated significant lateralization to the right cerebral hemisphere.
    • Uncovered maze traversal (fully visible mazes) activated areas 23 and 29 compared to controls.
    • Covered maze traversal (locally visible mazes) activated prefrontal areas 8, 10, and extrastriate area 19.

    Conclusions:

    • Spatial planning and navigation during maze traversal are predominantly processed in the right hemisphere.
    • The extrastriate cortex may serve as a storage site for path information.
    • Prefrontal cortical areas are involved in evoking spatial planning and navigation strategies.