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Related Experiment Videos

Sickle cell lung disease

E Tsou, S Katz

    American Family Physician
    |October 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Sickle cell disease patients with fever and lung infiltrates often have infection, but pulmonary infarction is a possibility. Differentiating between pneumonia and infarction requires considering patient age, symptoms, and lab findings.

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    Area of Science:

    • Hematology
    • Pulmonology
    • Infectious Diseases

    Background:

    • Sickle cell disease (SCD) presents unique challenges in diagnosing pulmonary complications.
    • Fever and lung infiltrates in SCD patients are commonly attributed to infection, but other causes exist.

    Purpose of the Study:

    • To differentiate between infectious pneumonia and pulmonary infarction in patients with sickle cell disease.
    • To identify clinical and laboratory features that distinguish these conditions.

    Main Methods:

    • Review of clinical presentations, imaging findings, and laboratory results in SCD patients with fever and lung infiltrates.
    • Comparison of features between patients diagnosed with pneumonia versus pulmonary infarction.

    Main Results:

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    • Pulmonary infarction can mimic pneumonia in SCD, even with negative cultures.
    • Pneumonia is more common in younger patients (<5 years) with purulent sputum and upper lobe infiltrates.
    • Thromboembolic disease is suggested by coexisting crisis, low leukocyte alkaline phosphatase, and microangiopathic changes.

    Conclusions:

    • Distinguishing pneumonia from pulmonary infarction in SCD requires careful evaluation of multiple factors.
    • Fat embolism syndrome, secondary to bone marrow necrosis, is a recognized complication in SCD.