Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutations that prevent associative learning in C. elegans

J Y Wen1, N Kumar, G Morrison

  • 1Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.

Behavioral Neuroscience
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dermal uptake of nicotine from air and clothing: Experimental verification.

Indoor air·2017
Same author

Advanced buffer materials for indoor air CO<sub>2</sub> control in commercial buildings.

Indoor air·2017
Same author

Spatial heterogeneity, population "regulation" and local extinction in simulated host-parasitoid interactions.

Oecologia·2017
Same author

Diagnostic accuracy of DXA compared to conventional spine radiographs for the detection of vertebral fractures in children.

European radiology·2016
Same author

Alignment and component position after patient-matched instrumentation versus conventional total knee arthroplasty.

Journal of orthopaedic surgery (Hong Kong)·2016
Same author

Measurements of dermal uptake of nicotine directly from air and clothing.

Indoor air·2016
Same journal

Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.

Behavioral neuroscience·2026
Same journal

Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.

Behavioral neuroscience·2026
Same journal

Defensive antinociception and antipredatory responses in prey threatened by distinct odoriferous cues from Felis silvestris catus.

Behavioral neuroscience·2026
Same journal

Taste exposure during different developmental phases impacts aversion learning in adult rats.

Behavioral neuroscience·2026
Same journal

Structural neuroanatomy of semantic retrograde memory in older adults.

Behavioral neuroscience·2026
Same journal

Oxytocin prevents cocaine-induced high-affect 50-kHz vocalizations in female rats.

Behavioral neuroscience·2026
See all related articles

This study demonstrates classical conditioning in the nematode Caenorhabditis elegans, identifying two mutant lines with impaired associative learning. These findings provide a foundation for understanding the molecular basis of learning and memory.

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Molecular Biology

Background:

  • The nematode Caenorhabditis elegans is a powerful model organism for studying fundamental biological processes.
  • Understanding the mechanisms of learning and memory is crucial in neuroscience.

Purpose of the Study:

  • To demonstrate classical conditioning in C. elegans.
  • To isolate and characterize mutants with defects in associative learning.
  • To establish a foundation for molecular and cellular analysis of associative learning.

Main Methods:

  • Classical conditioning assays were employed in C. elegans.
  • Behavioral characterization of wild-type and mutant C. elegans lines.
  • Assessment of associative and nonassociative learning, as well as sensorimotor function.

Related Experiment Videos

Main Results:

  • Successful demonstration of classical conditioning in C. elegans.
  • Isolation and identification of two mutant C. elegans lines exhibiting a complete block in associative learning.
  • Mutant lines showed normal nonassociative learning and sensorimotor function, indicating specificity of the defect.

Conclusions:

  • C. elegans is a suitable model for reductionist studies of learning and memory.
  • The identified mutants provide valuable tools for dissecting the cellular and molecular underpinnings of associative learning.
  • This work paves the way for detailed genetic and neuroanatomical investigations into the mechanisms of associative learning.