Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Frictional work in double-sided tablet compression

A Muñoz-Ruiz1, M Wihervaara, M Hakkinen

  • 1Department of Pharmaceutics, University of Kuopio, Finland.

Journal of Pharmaceutical Sciences
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bacteria associated with apical periodontitis promotes in vitro the differentiation of macrophages to osteoclasts.

Clinical oral investigations·2023
Same author

Severe Outbreak of Sorbitol-Fermenting Escherichia coli O157 via Unpasteurized Milk and Farm Visits, Finland 2012.

Zoonoses and public health·2017
Same author

Prevalence of Pathogenic Yersinia enterocolitica in Finnish Slaughter Pigs.

Journal of food protection·2016
Same author

The efficacy of a commercial competitive exclusion product on Campylobacter colonization in broiler chickens in a 5-week pilot-scale study.

Poultry science·2016
Same author

Raw grated beetroot linked to several outbreaks of sudden-onset gastrointestinal illness, Finland 2010.

Epidemiology and infection·2012
Same author

Factors related to the prevalence of pathogenic Yersinia enterocolitica on pig farms.

Epidemiology and infection·2011
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

This study introduces a new mathematical model to assess friction during double-sided tablet compression. The findings suggest compression profiles do not impact tablet strength, enabling better evaluation in pharmaceutical manufacturing.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Mechanical Engineering

Background:

  • Understanding friction is crucial for optimizing tablet compression processes.
  • Existing models primarily focus on single-sided compression, limiting applications for double-sided systems like rotary presses.

Purpose of the Study:

  • To develop and validate a novel mathematical expression for evaluating friction during double-sided tablet compression.
  • To investigate the influence of symmetrical and asymmetrical punch profiles on force transmission and material behavior.

Main Methods:

  • Utilized a compaction simulator with dicalcium phosphate dihydrate and lactose.
  • Employed symmetrical and asymmetrical double-sided sawtooth punch displacement profiles.
  • Derived a new friction work equation based on single-sided compression principles and force transmission estimations.

Related Experiment Videos

Main Results:

  • The derived equation accurately estimated friction work for double-sided compression, closely matching theoretical values.
  • Tablet tensile strength was consistent across single- and double-sided compression profiles, indicating material behavior independence from compression geometry.
  • The study established a method to predetermine material parameters (friction coefficient and Poisson's ratio) from single-sided compression.

Conclusions:

  • A novel mathematical expression for double-sided compression friction evaluation has been successfully developed.
  • The findings support the applicability of the new model for pharmaceutical processes, particularly in rotary press tabletting.
  • Material compression behavior is independent of the specific double-sided compression profile used.