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Related Experiment Videos

Parallel pathologies? Vulvar vestibulitis and interstitial cystitis

E G Stewart1, B M Berger

  • 1Stewart-Forbes Specialty Service, Harvard Pilgrim Health Care, Boston, Massachusetts, USA.

The Journal of Reproductive Medicine
|March 1, 1997
PubMed
Summary

Vulvar vestibulitis syndrome (VVS) vulvar epithelium shows no defects with Van Gieson staining. However, complement and IgM deposition were observed, similar to interstitial cystitis (IC).

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Area of Science:

  • Gynecologic Pathology
  • Vulvar Dermatology
  • Urogynecology

Background:

  • Interstitial cystitis (IC) is characterized by specific bladder epithelial defects and immunofluorescence.
  • Vulvar vestibulitis syndrome (VVS) is a poorly understood condition affecting the vulvar vestibule.

Purpose of the Study:

  • To investigate if similar epithelial defects observed in IC are present in VVS.
  • To determine if immunofluorescence patterns seen in IC are also present in VVS.

Main Methods:

  • Vulvar biopsies from 32 VVS patients and 30 controls were stained using Van Gieson stain.
  • Sixteen VVS vulvar biopsies were assessed for immunofluorescence.

Main Results:

  • Van Gieson staining did not reveal epithelial defects in VVS.

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  • Significant complement deposition (9/13 cases) and IgM deposition (7/13 cases) were found along the dermoepithelial junction and perivascular areas in VVS.

    • Conclusions:

    • Vulvar epithelium in VVS does not exhibit the defects seen in IC.
    • Complement and IgM deposition in VVS suggest potential vascular injury and altered neuronal processing, similar to IC.