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Related Experiment Videos

Controlling the capsular shape in lens refilling

O Nishi1, K Nishi, C Mano

  • 1Nishi Eye Hospital, Osaka, Japan.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

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The lens capsule can mold injected silicone, influencing refraction and accommodation. Moderate silicone refilling offers greater accommodative amplitude, suggesting potential for artificial lens research.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Optics

Background:

  • The human lens changes shape to focus light, a process called accommodation.
  • Understanding the biomechanical properties of the lens capsule is crucial for developing advanced intraocular lenses.

Purpose of the Study:

  • To assess the lens capsule's ability to shape injected silicone.
  • To investigate the relationship between injected silicone volume, refractive state, and accommodative amplitude.

Main Methods:

  • Pig eyes underwent endocapsular phacoemulsification and capsulorhexis.
  • The lens capsule was refilled with polymerizing silicone and sealed with a silicone plug.
  • Anterior capsule curvature and refraction were measured with and without induced zonular tension.

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Main Results:

  • The lens capsule molded the injected silicone, altering anterior curvature.
  • Accommodation amplitude varied with silicone volume, with moderate refilling yielding the greatest amplitude (e.g., 6.1 +/- 1.8 diopters at 55% volume).
  • Capsular curvature was affected by zonular tension, particularly at earlier time points.

Conclusions:

  • The lens capsule demonstrates viscoelastic properties, molding silicone during polymerization.
  • Achieving varying degrees of accommodation is possible through controlled silicone refilling.
  • Silicone plugs offer a reproducible method for lens refilling in research settings.