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Beta-cell function and insulin sensitivity in tropical calcific pancreatitis from north India
R N Mehrotra1, E Bhatia, G Choudhuri
1Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Metabolism: Clinical and Experimental
|April 1, 1997
Summary
Tropical calcific pancreatitis (TCP) leads to early-onset diabetes primarily due to impaired beta-cell function, not insulin resistance. This study investigated glucose intolerance in TCP patients, revealing key insights into its pathogenesis.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Gastroenterology
Background:
- Tropical calcific pancreatitis (TCP) is a distinct form of chronic pancreatitis prevalent in developing nations.
- TCP often results in premature diabetes mellitus, posing significant health challenges.
- The precise mechanisms underlying glucose intolerance in TCP remain incompletely understood.
Purpose of the Study:
- To elucidate the pathogenesis of glucose intolerance in patients with Tropical calcific pancreatitis.
- To differentiate the roles of beta-cell function and insulin sensitivity in TCP-associated diabetes.
Main Methods:
- Employed the continuous infusion of glucose with model assessment (CIGMA) technique.
- Measured beta-cell function (%B) and insulin sensitivity (%S) in TCP patients and healthy controls.
- Analyzed plasma glucose and insulin levels following intravenous glucose infusion.
Main Results:
- Insulin sensitivity (%S) was comparable across TCP patients (with and without hyperglycemia) and control groups.
- Beta-cell function (%B) was significantly reduced in TCP patients with hyperglycemia compared to controls and TCP patients with normal glucose tolerance.
- A negative correlation was observed between beta-cell function and the duration of pancreatitis in TCP patients.
Conclusions:
- The development of diabetes in Tropical calcific pancreatitis is primarily attributed to a decline in beta-cell function.
- Insulin resistance does not appear to be a major contributing factor to glucose intolerance in TCP.
- Understanding these mechanisms is crucial for managing diabetes in TCP patients.