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REM sleep behavior disorders in multiple system atrophy

G Plazzi1, R Corsini, F Provini

  • 1Institute of Clinical Neurology, University of Bologna, Italy.

Neurology
|April 1, 1997
PubMed
Summary
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REM sleep behavior disorder (RBD) is a common early sign in multiple system atrophy (MSA) patients, often preceding motor symptoms by years. Polysomnography confirms RBD in most MSA cases.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Neurodegenerative Diseases

Background:

  • Multiple system atrophy (MSA) is a progressive neurodegenerative disorder.
  • REM sleep behavior disorder (RBD) is characterized by the loss of muscle atonia during REM sleep.

Purpose of the Study:

  • To investigate the prevalence and timing of REM sleep behavior disorder (RBD) in patients with multiple system atrophy (MSA).
  • To identify polysomnographic findings associated with MSA.

Main Methods:

  • Clinical evaluation and polysomnographic investigations were performed on 39 consecutive MSA patients.
  • Patients were assessed for nocturnal motor episodes, dream-related activity, and onset of RBD relative to MSA symptoms.

Main Results:

Related Experiment Videos

  • REM sleep behavior disorder (RBD) was reported by 69% of patients and confirmed polysomnographically in 90% of MSA patients.
  • In 44% of cases, RBD preceded the onset of other MSA symptoms by over a year.
  • Other sleep disturbances included obstructive sleep apnea, laryngeal stridor, and periodic limb movements.

Conclusions:

  • REM sleep behavior disorder (RBD) is the most frequent clinical and polysomnographic finding in MSA.
  • RBD can serve as an early warning sign for MSA, appearing years before other clinical manifestations.
  • Extended polysomnographic recordings are recommended for MSA sleep studies.