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Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
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Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

[Rapid detection of rabies antibodies by immunoenzymatic assay]

P Atanasiu, V Savy, P Perrin

    Annales De Microbiologie
    |May 1, 1977
    PubMed

    Abstract:

    The antigen is a semipurified tissue culture virus, and peroxidase conjugated anti-human immunoglobulines are used. When sera from immunized humans are evaluated by this procedure, the values obtained show a good correlation with seroneutralization titres. The detection of antibodies by this method is earlier than by seroneutralization.

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    Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

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