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Blocking effect of vitamin C in exercise-induced asthma
1Pediatric Ambulatory Clinic, Rabin Medical Center, Petach Tiqva, Israel.
Archives of Pediatrics & Adolescent Medicine
|April 1, 1997
Summary
Vitamin C (ascorbic acid) may offer a protective effect for some individuals with exercise-induced asthma (EIA). While not universally effective, it showed promise in mitigating airway hyperreactivity in a subset of patients.
Area of Science:
- Pulmonology
- Clinical Nutrition
- Allergy and Immunology
Background:
- Exercise-induced asthma (EIA) is characterized by hyperreactive airways.
- The potential role of vitamin C (ascorbic acid) in managing EIA is not well-established.
Purpose of the Study:
- To investigate the protective effects of vitamin C on airway hyperreactivity in patients diagnosed with exercise-induced asthma.
- To assess the efficacy of oral ascorbic acid in preventing EIA symptoms.
Main Methods:
- A double-blind, placebo-controlled crossover study was conducted with 20 patients diagnosed with EIA.
- Participants received either 2g of oral ascorbic acid or a placebo before a standardized exercise challenge.
- Pulmonary function tests were performed at rest and post-exercise to evaluate airway response.
Main Results:
- Vitamin C administration did not alter resting pulmonary function.
- A protective effect against exercise-induced airway hyperreactivity was observed in 9 out of 20 patients.
- Continued low-dose vitamin C supplementation maintained this protective effect in a subgroup of responders.
Conclusions:
- The efficacy of vitamin C in preventing exercise-induced asthma is variable and cannot be predicted for all patients.
- Vitamin C may provide a beneficial protective effect on airway hyperreactivity for certain individuals with EIA.
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