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Related Experiment Videos

CD44: structure, function, and association with the malignant process

D Naor1, R V Sionov, D Ish-Shalom

  • 1Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Advances in Cancer Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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CD44 is a cell surface molecule with many forms, crucial for cell interactions and implicated in cancer. Targeting CD44-ligand interactions shows promise for cancer therapy by inhibiting tumor growth and metastasis.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • CD44 is a ubiquitous cell surface adhesion molecule involved in cell-cell and cell-matrix interactions.
  • Alternative splicing of 10 variable exons, along with post-translational modifications, generates over 20 CD44 isoforms.
  • Standard CD44 (CD44s) is found on hematopoietic cells, while variant isoforms (CD44v) are expressed on other cell types, including epithelial cells.

Purpose of the Study:

  • To provide a comprehensive overview of CD44 structure, function, and isoforms.
  • To explore the role of CD44 in cell adhesion, signaling, and matrix interactions.
  • To discuss the implications of CD44 expression in cancer diagnosis, prognosis, and therapeutic targeting.

Main Methods:

  • Review of existing literature on CD44 structure and function.

Related Experiment Videos

  • Analysis of CD44 alternative splicing and post-translational modifications.
  • Examination of CD44 ligand interactions, including hyaluronic acid (HA) and other extracellular matrix (ECM) components.

    • Main Results:

    • CD44 isoforms exhibit diverse molecular sizes (85-230 kDa) and functions.
    • CD44 mediates critical cellular processes like cell trafficking, signaling, and matrix uptake.
    • Aberrant CD44 expression, particularly variants, is observed in various cancers, correlating with disease progression.

    Conclusions:

    • CD44 is a multifunctional molecule with significant roles in normal physiology and disease.
    • CD44 variants serve as potential diagnostic and prognostic markers for human malignancies.
    • Targeting CD44-ligand interactions represents a promising strategy for novel cancer therapies.