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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[Measles with respiratory involvement in adults. 2 cases]
Y Loubières1, T Fourme, B Page
1Service de Réanimation polyvalente, Hôpital Ambroise Paré, Boulogne.
Background:
Measles is usually considered to be a childhood disease. Recent epidemiology data suggest that it is in progress amongst the adult population despite generalized vaccination.
Case Report:
Within a 3-week period, two brothers, aged 19 and 21 years, developed fever and interstitial pneumonia. Characteristic maculopapulous eruptions occurred later leading to measles diagnosis.
Discussion:
Although the clinical course is usually benign, measles can cause severe complications, particularly respiratory involvement that occurs in 3 to 10% of adult measles cases. The virus can affect the respiratory epithelium directly leading to bronchopneumonia which develops prior to the cutaneous eruption; all manifestations then regress together as in our two cases. Later complications due to bacterial superinfections can occur. Measles should be considered in adults with fever and interstitial pneumonia.
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